Intermittent fasting and bariatric surgery have different outcomes in MS

Recent research suggests that bariatric surgery may have an unintended consequence of worsening MS.

Obesity in multiple sclerosis has been associated with increased relapses and disease progression. Additionally, a high body mass index (BMI) is strongly associated with an increased risk of MS, according to a 2018 study.

While intermittent fasting improved MS symptoms according to new research, another study on bariatric surgery for weight loss said surgeries may have a negative impact on MS.

In a study published in Multiple Sclerosis Journal, Anna Karin Hedstrom, a senior research specialist at the Karolinska Institutet in Stockholm, Sweden, and her colleagues compared disease outcomes in 122 MS cases who underwent metabolic surgery with those in 122 MS cases without surgery.

They found that the time to confirmed disability progression over 6 months during the first 5 years after inclusion was shorter in bariatric surgery patients (risk ratio (HR) = 2.31, 1 .09–4.90; p= 0.03).

The researchers did not observe differences in the annual postoperative relapse rate (p= 0.24) or time to first postoperative relapse (p= 0.52).

“Although metabolic surgery appears to be a safe and effective treatment for obesity in MS patients, the clinical course of the disease could be negatively affected,” Hedstrom wrote. “Long-term nutritional follow-up after surgery and maintenance of supplementation are crucial, especially in people with preoperative deficits.”

Meanwhile, a separate study published in The Lancet found that restricting calories for two days a week reduced certain immune cells and molecules involved in lipid metabolism (fat processing) in people with MS.

Kathryn C. Fitzgerald, assistant professor of neurology at Johns Hopkins University School of Medicine, and her colleagues compared three diets: a control diet (100% of calorie needs 7 days/week), a calorie restriction diet daily (78% of calorie needs 7 days/week). days/week), and an intermittent calorie restriction diet, or intermittent fasting (25% of calories need 2 consecutive days/week; 100% of calories need 5 days/week).

Compared to the control diet, both calorie restriction diets resulted in weight loss and improved emotional well-being.

Additionally, intermittent fasting reduced certain immune T cells (such as some implicated in MS immune attacks), increased other types of T cells, and altered levels of molecules involved in lipid metabolism. said the National Multiple Sclerosis Society, which sponsored the study. in a report.

Further larger studies are needed to confirm the findings and determine whether they indicate that diet can directly reduce MS-related disease activity, the company said.

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