Weight loss diets are a great way to shed those extra pounds. According to studies, our body prefers to compensate by saving energy, decreasing the number of calories we burn, and therefore affecting our weight loss program.
According to the findings, a set of neurons in the hypothalamus, known as the agouti-related neuropeptide (AGRP), contribute to the calorie thermostat, which controls our weight by regulating the number of calories we burn.
When these neurons are active, they make us hungry and want to eat, but when there is no food available, they make up for lost calories.
“Our results suggest that AGRP in the brain coordinates appetite and energy expenditure, and may flip a switch on and off to burn or save calories depending on what is available in the environment,” said Clémence Blouet. from the University of Cambridge in Great Britain.
“When we eat less, our body adapts by burning fewer calories, which makes it harder to lose weight,” Blouet explained.
However, as soon as food is available and we start eating, the function of AGRP neurons is disrupted and our energy expenditure returns to normal levels.
The researchers discovered a new process by which the body adapts to low calorie intake and reduced weight loss in mice in their study, which was published in the journal eLife.
They rapidly and reversibly altered the activity of AGRP neurons in mice using a genetic trick to turn them on and off, a discovery that could aid in the development of new or improved drugs to help reduce overeating and overeating. obesity in the future, according to the researchers. . According to an Indianexpress article.
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